The effective timeline is really an individual experience. In most cases, you should feel improvement in two weeks. Our supplement is not a simple medicine that targets a simple symptom, it works on the foundation of your body and is targeted to improve your health systemically and thoroughly. So, it needs time to work with your body. You may feel an apparent difference in as little as one week. We have clients who have experienced protracted problems that reported life-enhancing results within a month of taking GI Balance.